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The federal government is calling off around $500 million worth of vaccine development projects that use mRNA technology, Secretary of Health and Human Services Robert F. Kennedy Jr. announced Tuesday.

The 22 now-terminated projects were funded through the Biomedical Advanced Research and Development Authority, or BARDA. Most of the projects that were canceled were for vaccines that fight COVID-19 or the flu, Kennedy .

They include proposals from Pfizer, Sanofi Pasteur and other drugmakers that were rejected or canceled, along with to develop a bird flu vaccine, according to an HHS statement. The projects were reviewed and canceled over the last few weeks, said Kennedy.

A Moderna spokesperson told TheNews that the company's H5N1 (bird flu) contract was canceled in May, and it isn't aware of any new BARDA cancellations.

Kennedy as part of a step away from research into mRNA vaccines. Those types of vaccines  messenger RNA, or mRNA, to prompt the body to make proteins that induce antibody production to protect against an infection. The approach has drawn more interest since the COVID-19 pandemic, when mRNA vaccines by Pfizer and Moderna were  against the coronavirus. Public health officials credit the rapid development of the vaccines with .

Nevertheless, Kennedy said, "HHS has determined that mRNA technology poses more risk than benefits for these respiratory viruses." 

He argued mRNA-based vaccines can stop working properly if the virus that they target mutates too much, citing  as an example. "A single mutation can make mRNA vaccines ineffective," Kennedy said. 

Leading infectious disease experts criticized the decision and said it will leave Americans vulnerable.

Dr. Paul Offit, a virologist and vaccine expert at Children's Hospital of Philadelphia, said Kennedy "has once again made a decision, not based on scientific evidence that puts this country at unnecessary risk."

Epidemiologist Dr. Michael Osterholm called it "one of the worst decisions I've seen in 50 years of public health preparedness work." 

"If an influenza pandemic hit us tomorrow, the global flu vaccine manufacturing capacity using the standard method of growing the virus in chicken eggs would only produce enough vaccine in 18 months to vaccinate just one fourth of the world," he told TheNews. "We desperately need a vaccine technology where we could make enough vaccine for the world in a year."

Many of mRNA vaccines is that they can be developed, manufactured and changed quickly, allowing drugmakers and public health officials to to novel viruses and to constantly mutating viruses like the flu.

In 2020, the first Trump administration funded the development of Pfizer and Moderna's mRNA COVID-19 vaccines, which were developed significantly faster than traditional vaccines.

"No other nation matched what America achieved during the pandemic," Dr. Luciana Borio, former director for medical and biodefense preparedness at the National Security Council, told TheNews. "We pioneered and delivered life-saving mRNA vaccines at unprecedented speed. It's a historic accomplishment we should celebrate. Clinging to outdated technologies to counter a future flu pandemic is a grave mistake." 

Kennedy has a  of  about vaccines. Since he joined the Trump administration, he has of an expert panel that made vaccine recommendations, and announced the for children and healthy pregnant women to get vaccinated against COVID-19. The Centers for Disease Control and Prevention and that it is safe and beneficial for pregnant women.

Kennedy said Tuesday that HHS is moving the now-canceled funding to "safer, broader vaccine platforms that remain effective even as viruses mutate."

"Let me be absolutely clear: HHS supports safe, effective vaccines for every American who wants them," the health secretary said.